Cleveland Guardians host Chicago White Sox in the MLB on Tuesday 15 September 2026, with the start at 6:40 pm EDT. The match is at Progressive Field, Cleveland. That is 11:40 pm in London, 6:40 pm in New York and 3:40 pm in Los Angeles.
MLB is the top professional baseball league in North America, with a very long regular season played almost daily from spring to autumn before a postseason of short series. Starting pitching is the single biggest factor in any matchup, while ballpark dimensions, weather and bullpen fatigue also shape individual games.
Baseball turns on the starting pitcher matchup, bullpen availability and how tired the relief corps is after a dense run of games. Park dimensions, wind direction and temperature change how far batted balls travel, so run totals move with conditions. Long schedules force rest days, and lineups can look very different on consecutive days. Interest usually sits on the run line, the total, first five innings markets and strikeout counts.
Add the event to your calendar to keep the start time as the schedule is confirmed. Kick-off times are checked against the official schedule every week, so this page follows any change.